cystic fibrosis

Cystic Fibrosis: Personalized Treatment with Pharmacogenetics

BioCertica Content Team

Cystic fibrosis (CF) is a condition passed down through families that mainly affects the lungs and digestive system. It makes the lungs get damaged over time and causes problems with digesting food. This happens because of issues with a gene called CFTR. This gene is supposed to help move salts in and out of our cells, but in CF, it needs to be fixed. Doctors usually try to help people with CF by treating the symptoms and trying to stop more problems from happening.

Dealing with Cystic Fibrosis

Treating CF can be tricky. It often involves things like special breathing exercises, medicines you breathe in, pills to help with digestion and antibiotics. However how well these treatments work can be different for everyone because of differences in the CFTR gene and other genes that can change how medicines work in the body.


How Genetics Can Help


There's this cool area of study called pharmacogenetics, which looks at how your genes affect the way you respond to medicines. This is super important for CF because it can help doctors determine the best treatment for each person based on their genetic makeup. This could mean better results from treatment and fewer side effects.


New Treatments Tailored to Your Genes


Lately, there have been some exciting developments in treatments that specifically target the faulty CFTR protein in CF. These treatments, known as CFTR modulators, can help correct the problem caused by the gene mutation. But, which treatment will work best depends on the exact type of gene mutation a person has, so genetic testing is a big deal.


Making Pharmacogenetics a Part of CF Care 


To use pharmacogenetics in CF care, patients need to get genetic testing to find out their specific type of CFTR mutation. This info helps pick out the right treatments to match their genetic profile, aiming to get the best results. This approach needs everyone involved - patients, doctors, and genetic experts - to work closely together.


BioCertica's Pharmacogenetics Test

BioCertica is on the cutting edge with a pharmacogenetics test that looks at the genes of people with CF. This test checks out which gene variations might affect how well CF medicines work for someone.


With this test, doctors can better decide on treatments that are more likely to be effective and safe, helping to avoid guesswork and improve health outcomes.


Using pharmacogenetics in CF is changing the game in how we treat this condition, making treatments more personal. BioCertica's test is leading the way, helping to match treatments with patients' genetic profiles. This approach is opening up new possibilities for better health and well-being for people with CF, marking the start of a new chapter in personalized medicine.


Carter, S. C., & McKone, E. F. (2016). Pharmacogenetics of cystic fibrosis treatment. Pharmacogenomics, 17(13), 1453-1463.

Sakon, C., Alicea, L. A., Patacca, H., Brown, C. D., Skaar, T. C., & Tillman, E. M. (2022). Opportunity for pharmacogenomic testing in patients with cystic fibrosis. Pediatric Pulmonology, 57(4), 903-907.

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