Methylation: MTHFR Status and Your B Vitamin Needs

Methylation: MTHFR Status and Your B Vitamin Needs

Jamie Fernandez

Methylation, a critical biochemical process, plays a pivotal role in our health, particularly through its influence on DNA synthesis and repair. Central to this process is the MTHFR (Methylenetetrahydrofolate Reductase) enzyme, a key player in metabolizing folic acid, a crucial B-vitamin. Folic acid's importance cannot be overstated, as it is essential for DNA synthesis, cell division, and the production of red blood cells. The activity of the MTHFR enzyme, influenced by variations in the MTHFR gene, significantly impacts an individual's dietary needs.

At BioCertica, we delve into one's methylation process by analyzing two prevalent MTHFR gene variants: C677T and A1298C. The presence of the C677T variant can reduce MTHFR activity by approximately 70%, whereas the A1298C variant might lower it by 30-40%. Individuals carrying one copy of either variant are referred to as heterozygous, while those with two copies, one from each parent, are homozygous.

Implications of MTHFR Gene Variants

For individuals with MTHFR gene variants, the reduced enzyme activity may necessitate increased intake of folic acid (vitamin B9) and other B-vitamins, such as B6 and B12. This is because their bodies might struggle to efficiently metabolize these essential nutrients. Research has suggested that people with these genetic variations could also experience elevated levels of homocysteine, an amino acid that, at high levels, is associated with an increased risk of cardiovascular diseases, stroke, and neural tube defects.

To address these elevated dietary needs, those affected may find it beneficial to consume foods rich in B-vitamins, including leafy greens, legumes, nuts, and seeds. Moreover, supplementing with a high-quality B-complex vitamin could be advantageous, ensuring the adequate intake of necessary B-vitamins.

It's crucial to recognize that not everyone with MTHFR gene variants will face health complications or require dietary adjustments. Nonetheless, if you're concerned about your MTHFR gene status, consulting with a healthcare provider or genetic counselor is advisable. They can offer guidance tailored to your unique needs and circumstances.


MTHFR gene variants significantly influence one's dietary requirements, underscoring the need for individuals with these variants to ensure sufficient intake of B-vitamins. Through mindful dietary choices and potential supplementation, those affected can support their health effectively, promoting overall well-being. As we continue to explore the connections between methylation, DNA, MTHFR, and health, it becomes increasingly clear how critical our genetic makeup is in determining our nutritional needs and health outcomes.


Written by: Jonine Möller, M.Sc. in Sport Science

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